Hepatic Glucose 6 Phosphate Dehydrogenase (G6PD) plays a pivotal role in the Pentose Phosphate Pathway, generating NADPH for antioxidant defense and supporting nucleotide & amino acid biosynthesis. G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Glucose 6 Phosphate Dehydrogenase (G6PD) Deficiency The Medical Biochemistry Page Diabetes causes inhibition of glucose 6 phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex American Journal of Physiology Renal Physiology American Physiological Society Glutathione Reductase (GR) The Scout for Liver Health The Controversial Role of Glucose6Phosphate Dehydrogenase Deficiency on Cardiovascular Disease: A Narrative Review Dore 2021 Oxidative Medicine and Cellular Longevity Wiley Online Library