Cagrilintide: The Next Gen Peptide for Weight Loss and Satiety Hubmed Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity New England Journal of Medicine Cagrilintide (AM833) Long acting amylin analog. Beta cells make TWO hormones: insulin and amylin. Amylin slows stomach emptying and reduces appetite. Cagrilintide is a long acting synthetic amylin designed for once weekly dosing Amylin Commands Weight Loss Attention as Industry Anticipates Novo's Phase III CagriSema Readout BioSpace Semaglutide and cagrilintide have each been shown to induce weight loss, but how these drugs work in combination in patients with type 2 diabetes and overweight or obesity is unknown. Research findings CagriSema Reduces Blood Pressure in Adults With Overweight or Obesity: REDEFINE 1 Hypertension