USMLE Step 2 CK Question of the Day: Altered Mental State After Over the counter pain reliever and Prescription Hydrocodone acetaminophen Osmosis Blog Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. 05. Acetaminophen Toxicity Hospital Handbook Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology Paracetamol (Acetaminophen) and the Developing Brain