Sex differences in glutathione metabolism and acetaminophen toxicity Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model Theoretical Biology and Medical Modelling Springer Nature Link Sex differences in glutathione metabolism and acetaminophen toxicity Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.