Tylenol And Glutathione Invigor Medical Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram GlutaPro RX Glutathione Supplement Olivia Quido O Skin Med Spa Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression Nature Communications Glutathione: Benefits and Supplements