Freckle on Lip: Meaning, Causes and Is It Dangerous? (Labial Melanotic Macule) La Bouche Parfaite What Caused These Multiple Hyperpigmented Macules of the Mouth? Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in Melanotic Macules, Naevi, and Melanoma Springer Nature Link Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review Labial Melanotic Macules in Atopic Dermatitis: An Observational Study Semantic Scholar