Can You Donate Blood If You Smoke? Cannabis, Nicotine, and More Can You Donate Blood If You Smoke? Cannabis, Nicotine, and More Ohio Woman Has 'Black and Bloody' Vape Juice Removed from Lungs Just How Harmful Is Vaping? More Evidence Is Emerging. The New York Times Can you donate blood if you smoke? We all know smoking and vaping isn't great for your health. But it doesn't stop you from being a blood or plasma donor. Just make sure to wait one hour after donating